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KMID : 1098420090170020109
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 2 p.109 ~ p.114
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Comparative Study of Extracts from Rhubarb on Inflammatory Activity in Raw 264.7 Cells
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Cheon Myeong-Sook
Yoon Tae-Sook
Choi Go-Ya
Kim Seung-Ju
Lee A-Young
Moon Byeong-Cheol
Choo Byung-Kil
Kim Ho-Kyoung
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Abstract
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Rhubarb is the well-known and frequently used herbal medicine for the treatment of constipation, inflammation, and cancer. As described in the Korea and Chinese Pharmacopoeia, rhubarb consists of the roots and rhizomes of Rheum palmatum, R. officinale, and R. tanguticum. However, the pharmacological differences among rhubarb have not been scientifically established. In the present study, we investigated and compared the inhibitory effects of 70% ethanolic extracts from R. palmatum (RPE), R. officinale (ROE), R. nobile (RNE), and R. franzenbachii (RFE) on the production of inflammatory mediators, nitric oxide (NO), prostaglandin (), interlukin-1beta (), and tumor necrosis factor-alpha () in RAW 264.7 macrophage cells. ROE, RNE, and RFE significantly inhibited the release of NO, , , and . RPE significantly reduced the release of , but not NO, , and . Overall, RFE was found to inhibit the release of and , to a far greater degree than RPE, ROE, and RNE. Our results indicate that RFE possess the strongest anti-inflammatory activity among 4 tested rhubarb.
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KEYWORD
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Anti-inflammation, Inflammatory Mediators, Rheum franzenbachii, Rheum nobile, Rheum officinale, Rheum palmatum
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